Physiological carbon dioxide, bicarbonate, and pH sensing Review uri icon

Overview

MeSH Major

  • Bicarbonates
  • Carbon Dioxide

abstract

  • In biological systems, carbon dioxide exists in equilibrium with bicarbonate and protons. The individual components of this equilibrium (i.e., CO₂, HCO₃⁻, and H(+)), which must be sensed to be able to maintain cellular and organismal pH, also function as signals to modulate multiple physiological functions. Yet, the molecular sensors for CO₂/HCO₃⁻/pH remained unknown until recently. Here, we review recent progress in delineating molecular and cellular mechanisms for sensing CO₂, HCO₃⁻, and pH.

publication date

  • November 2010

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC2967379

Digital Object Identifier (DOI)

  • 10.1007/s00424-010-0865-6

PubMed ID

  • 20683624

Additional Document Info

start page

  • 953

end page

  • 64

volume

  • 460

number

  • 6