Expression of master regulatory genes controlling skeletal development in benign cartilage and bone forming tumors Academic Article uri icon


MeSH Major

  • Bone Neoplasms
  • Cartilage
  • Gene Regulatory Networks
  • Neoplasms, Connective Tissue
  • Osteogenesis
  • Transcription Factors


  • Recent progress in skeletal molecular biology has led to the clarification of the transcriptional mechanisms of chondroblastic and osteoblastic lineage differentiation. Three master transcription factors-Sox9, Runx2, and Osterix-were shown to play an essential role in determining the skeletal progenitor cells' fate. The present study evaluates the expression of these factors in 4 types of benign bone tumors-chondromyxoid fibroma, chondroblastoma, osteoid osteoma, and osteoblastoma-using immunohistochemistry and tissue microarrays. Osteoid osteoma and osteoblastoma showed strong nuclear expression of Osterix and Runx2. In contrast, only a few chondroblastomas showed positive nuclear expression of Osterix. Strong nuclear expression of Sox9 was detected in all chondroblastomas, whereas nearly half of the osteoblastomas showed focal weak cytoplasmic expression of Sox9.

publication date

  • December 2010



  • Academic Article



  • eng

PubMed Central ID

  • PMC4012830

Digital Object Identifier (DOI)

  • 10.1016/j.humpath.2010.06.008

PubMed ID

  • 21078438

Additional Document Info

start page

  • 1788

end page

  • 93


  • 41


  • 12