AntiCTLA-4 antibody therapy: Immune monitoring during clinical development of a novel immunotherapy Review uri icon

Overview

MeSH Major

  • Antibodies, Monoclonal
  • Antigens, CD
  • Antineoplastic Agents
  • Melanoma
  • Monitoring, Immunologic
  • Skin Neoplasms

abstract

  • Cytotoxic T-lymphocyte-associated antigen (CTLA-4), also known as CD152, is a co-inhibitory molecule that functions to regulate T-cell activation. Antibodies that block the interaction of CTLA-4 with its ligands B7.1 and B7.2 can enhance immune responses, including antitumor immunity. Two CTLA-4-blocking antibodies are presently under clinical investigation: ipilimumab and tremelimumab. CTLA-4 blockade has shown promise in treatment of patients with metastatic melanoma, with a recently completed randomized, double-blind phase III trial demonstrating a benefit in overall survival (OS) in the treated population. However, this approach appears to benefit only a subset of patients. Understanding the mechanism(s) of action of CTLA-4 blockade and identifying prognostic immunologic correlates of clinical endpoints to monitor are presently areas of intense investigation. Several immunologic endpoints have been proposed to correlate with clinical activity. This review will focus on the endpoints of immune monitoring described in studies to date and discuss future areas of additional work needed.

publication date

  • October 2010

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3008567

Digital Object Identifier (DOI)

  • 10.1053/j.seminoncol.2010.09.001

PubMed ID

  • 21074063

Additional Document Info

start page

  • 473

end page

  • 84

volume

  • 37

number

  • 5