TSLP polymorphisms are associated with asthma in a sex-specific fashion. Academic Article uri icon

Overview

MeSH

  • African Continental Ancestry Group
  • Child
  • Cohort Studies
  • Costa Rica
  • European Continental Ancestry Group
  • Female
  • Genome-Wide Association Study
  • Genotype
  • Hispanic Americans
  • Humans
  • Male
  • Polymorphism, Single Nucleotide
  • Risk Factors

MeSH Major

  • Asthma
  • Cytokines
  • Genetic Predisposition to Disease
  • Sex Characteristics

abstract

  • Single nucleotide polymorphisms (SNPs) in thymic stromal lymphopoietin (TSLP) have been associated with IgE (in girls) and asthma (in general). We sought to determine whether TSLP SNPs are associated with asthma in a sex-specific fashion. We conducted regular and sex-stratified analyses of association between SNPs in TSLP and asthma in families of children with asthma in Costa Rica. Significant findings were replicated in whites and African-American participants in the Childhood Asthma Management Program, in African-Americans in the Genomic Research on Asthma in the African Diaspora study, in whites and Hispanics in the Children's Health Study, and in whites in the Framingham Heart Study (FHS). Two SNPs in TSLP (rs1837253 and rs2289276) were significantly associated with a reduced risk of asthma in combined analyses of all cohorts (P values of 2 × 10(-5) and 1 × 10(-5) , respectively). In a sex-stratified analysis, the T allele of rs1837253 was significantly associated with a reduced risk of asthma in males only (P = 3 × 10(-6) ). Alternately, the T allele of rs2289276 was significantly associated with a reduced risk of asthma in females only (P = 2 × 10(-4) ). Findings for rs2289276 were consistent in all cohorts except the FHS. TSLP variants are associated with asthma in a sex-specific fashion. © 2010 John Wiley & Sons A/S.

publication date

  • December 2010

has subject area

  • African Continental Ancestry Group
  • Asthma
  • Child
  • Cohort Studies
  • Costa Rica
  • Cytokines
  • European Continental Ancestry Group
  • Female
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Genotype
  • Hispanic Americans
  • Humans
  • Male
  • Polymorphism, Single Nucleotide
  • Risk Factors
  • Sex Characteristics

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2970693

Digital Object Identifier (DOI)

  • 10.1111/j.1398-9995.2010.02415.x

PubMed ID

  • 20560908

Additional Document Info

start page

  • 1566

end page

  • 1575

volume

  • 65

number

  • 12