Expression of CD39 by human peripheral blood CD4+CD25 + T cells denotes a regulatory memory phenotype Academic Article uri icon


MeSH Major

  • Antigens, CD
  • Antigens, CD4
  • Apyrase
  • CD4-Positive T-Lymphocytes
  • Pyrophosphatases
  • T-Lymphocytes, Regulatory


  • We have shown that CD39 and CD73 are coexpressed on the surface of murine CD4+ Foxp3+ regulatory T cells (Treg) and generate extracellular adenosine, contributing to Treg immunosuppressive activity. We now describe that CD39, independently of CD73, is expressed by a subset of blood-derived human CD4+ CD25+ CD127lo Treg, defined by robust expression of Foxp3. A further distinct population of CD4+ CD39+ T lymphocytes can be identified, which do not express CD25 and FoxP3 and exhibit the memory effector cellular phenotype. Differential expression of CD25 and CD39 on circulating CD4+ T cells distinguishes between Treg and pathogenic cellular populations that secrete proinflammatory cytokines such as IFN╬│ and IL-17. These latter cell populations are increased, with a concomitant decrease in the CD4+ CD25+ CD39+ Tregs, in the peripheral blood of patients with renal allograft rejection. We conclude that the ectonucleotidase CD39 is a useful and dynamic lymphocytes surface marker that can be used to identify different peripheral blood T cell-populations to allow tracking of these in health and disease, as in renal allograft rejection.

publication date

  • November 2010



  • Academic Article



  • eng

PubMed Central ID

  • PMC2966025

Digital Object Identifier (DOI)

  • 10.1111/j.1600-6143.2010.03291.x

PubMed ID

  • 20977632

Additional Document Info

start page

  • 2410

end page

  • 20


  • 10


  • 11