Mouse models of inherited cancer syndromes. Review uri icon

Overview

MeSH

  • Animals
  • Humans
  • Mice
  • Mice, Knockout
  • Mutation

MeSH Major

  • Disease Models, Animal
  • Genetic Predisposition to Disease
  • Neoplastic Syndromes, Hereditary

abstract

  • Animal models of cancer have been instrumental in understanding the progression and therapy of hereditary cancer syndromes. The ability to alter the genome of an individual mouse cell in both constitutive and inducible approaches has led to many novel insights into their human counterparts. In this review, knockout mouse models of inherited human cancer syndromes are presented and insights from the study of these models are highlighted. Copyright © 2010 Elsevier Inc. All rights reserved.

publication date

  • December 2010

has subject area

  • Animals
  • Disease Models, Animal
  • Genetic Predisposition to Disease
  • Humans
  • Mice
  • Mice, Knockout
  • Mutation
  • Neoplastic Syndromes, Hereditary

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3011940

Digital Object Identifier (DOI)

  • 10.1016/j.hoc.2010.08.011

PubMed ID

  • 21075289

Additional Document Info

start page

  • 1205

end page

  • 1228

volume

  • 24

number

  • 6