Diagnostic challenges in the pathologic evaluation of barrett esophagus Review uri icon

Overview

MeSH Major

  • Barrett Esophagus
  • Esophagogastric Junction
  • Esophagus
  • Gastroesophageal Reflux

abstract

  • Barrett esophagus is currently defined as the presence of intestinal metaplasia in samples obtained from an endoscopically evident abnormality in the distal esophagus. Diagnosis and grading of dysplasia in mucosal biopsies remain the most reliable method to assess risk for neoplastic progression, but its classification may be hindered by superimposed inflammatory changes and suffers from considerable interobserver variability. Therefore, immunohistochemical studies and molecular assessment for TP53, CDKN2A , and DNA content abnormalities have emerged as potential adjuncts to the detection of dysplasia.

publication date

  • November 2010

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 21043812

Additional Document Info

start page

  • 1589

end page

  • 600

volume

  • 134

number

  • 11