Temsirolimus has activity in non-mantle cell non-Hodgkin's lymphoma subtypes: The University of Chicago phase II consortium Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Intracellular Signaling Peptides and Proteins
  • Lymphoma, Non-Hodgkin
  • Protein Kinase Inhibitors
  • Protein-Serine-Threonine Kinases
  • Sirolimus

abstract

  • Single-agent temsirolimus has significant activity in both diffuse large B-cell lymphoma and follicular lymphoma, although the durability of responses and PFS are longer for patients with follicular lymphoma. This is the first report of substantial activity of temsirolimus in lymphomas other than mantle cell lymphoma, and supports further evaluation of mTOR as a target in these diseases.

publication date

  • November 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3020703

Digital Object Identifier (DOI)

  • 10.1200/JCO.2010.29.2813

PubMed ID

  • 20837940

Additional Document Info

start page

  • 4740

end page

  • 6

volume

  • 28

number

  • 31