ICOStomizing immunotherapies with TH17 Article uri icon

Overview

MeSH Major

  • Antigens, Differentiation, T-Lymphocyte
  • Immunotherapy
  • Signal Transduction
  • Th17 Cells

abstract

  • New insights on the role of costimulatory molecules in T helper cell function have yielded exciting alternatives to the development of therapeutic strategies that target T cell costimulatory pathways. Inducible costimulatory molecule (ICOS) signaling is now shown by Paulos and colleagues to support expansion of human T helper 17 (T(H)17) cells that could exert antitumor activity. Here we discuss (i) how these findings aid in our understanding of mechanisms that govern T(H)17 cell functions and (ii) the potential application of these new insights to the development of immunotherapies.

publication date

  • October 27, 2010

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1126/scitranslmed.3001722

Additional Document Info

start page

  • 55ps52

volume

  • 2

number

  • 55