Cholesterol pathways affected by small molecules that decrease sterol levels in niemann-pick type C mutant cells Academic Article uri icon

Overview

MeSH Major

  • Anticholesteremic Agents
  • Cholesterol
  • Mutation
  • Niemann-Pick Diseases
  • Small Molecule Libraries
  • Sterols

abstract

  • Results herein provide the information for prioritized further studies in identifying molecular targets of the chemicals. This approach proved successful in the identification of seven chemicals as novel inhibitors of lysosomal acid lipase (Rosenbaum et al, Biochim. Biophys. Acta. 2009, 1791:1155-1165).

publication date

  • October 29, 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2943465

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0012788

PubMed ID

  • 20877719

Additional Document Info

start page

  • e12788

volume

  • 5

number

  • 9