Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery Academic Article uri icon

Overview

MeSH Major

  • Cell Membrane
  • Endothelial Cells
  • Neoplasms
  • Neovascularization, Pathologic
  • Radiation-Sensitizing Agents
  • Radiosurgery

abstract

  • These studies show that angiogenic factors fail to suppress apoptosis if ceramide remains elevated while anti-angiogenic therapies fail without ceramide elevation, defining a ceramide rheostat that determines outcome of single dose radiotherapy. Understanding the temporal sequencing of anti-angiogenic drugs and radiation enables optimized radiosensitization and design of innovative radiosurgery clinical trials.

publication date

  • October 20, 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2924400

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0012310

PubMed ID

  • 20808818

Additional Document Info

start page

  • e12310

volume

  • 5

number

  • 8