Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival Academic Article uri icon

Overview

MeSH Major

  • Body Mass Index
  • Fatty Acid Synthases
  • Polymorphism, Single Nucleotide
  • Prostatic Neoplasms

abstract

  • FASN germline polymorphisms were significantly associated with risk of lethal PCa. Significant interactions of BMI with FASN polymorphisms and FASN tumor expression suggest FASN as a potential link between obesity and poor PCa outcome and raise the possibility that FASN inhibition could reduce PCa-specific mortality, particularly in overweight men.

publication date

  • September 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2940394

Digital Object Identifier (DOI)

  • 10.1200/JCO.2009.27.0793

PubMed ID

  • 20679621

Additional Document Info

start page

  • 3958

end page

  • 64

volume

  • 28

number

  • 25