Sevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1 Academic Article uri icon

Overview

MeSH Major

  • Allosteric Site
  • Lymphocyte Function-Associated Antigen-1
  • Methyl Ethers

abstract

  • This study suggests that sevoflurane also blocks the activation-dependent conformational changes of LFA-1 to the high-affinity form. The allosteric mode of action exemplified by sevoflurane and isoflurane via LFA-1 might represent one of the underlying mechanisms of anesthetic-mediated immunomodulation.

publication date

  • September 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5209785

Digital Object Identifier (DOI)

  • 10.1097/ALN.0b013e3181e89a77

PubMed ID

  • 20693879

Additional Document Info

start page

  • 600

end page

  • 9

volume

  • 113

number

  • 3