Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells Academic Article uri icon

Overview

MeSH Major

  • Aldehyde Dehydrogenase
  • Arrhythmias, Cardiac
  • Mast Cells
  • Myocardial Reperfusion Injury
  • Myocytes, Cardiac
  • Renin

abstract

  • The results uncover a signaling cascade initiated by A(2b)/A(3) receptors, which triggers PKCepsilon-mediated ALDH2 activation in cardiac mast cells, contributing to IPC-induced cardioprotection by preventing mast cell renin release and the dysfunctional consequences of local RAS activation. Thus, unlike classic IPC in which cardiac myocytes are the main target, cardiac mast cells are the critical site at which the cardioprotective anti-RAS effects of IPC develop.

publication date

  • August 24, 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2927811

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.110.952481

PubMed ID

  • 20697027

Additional Document Info

start page

  • 771

end page

  • 81

volume

  • 122

number

  • 8