Evaluation of early dementia (Mild cognitive impairment) Report uri icon


MeSH Major

  • Alzheimer Disease
  • Amyloid
  • Brain
  • Cognition Disorders
  • Positron-Emission Tomography


  • Early diagnosis of Alzheimer disease (AD) is one of the major challenges for the prevention of this dementia. The pathologic lesions associated with AD develop many years before the clinical manifestations of the disease become evident, during a likely transitional period between normal aging and the appearance of first cognitive symptoms. AD biomarkers are needed not only to reveal these early pathologic changes but also to monitor progression in cognitive and behavioral decline and brain lesions. PET neuroimaging can reliably assess indirect and direct aspects of the molecular biology and neuropathology of AD. This article reviews the use of [18F] 2-fluoro-2-deoxy-D- glucose-PET and amyloid PET imaging in the early detection of AD. © 2010 Elsevier Inc.

publication date

  • January 2010



  • Report


Digital Object Identifier (DOI)

  • 10.1016/j.cpet.2009.12.003

Additional Document Info

start page

  • 15

end page

  • 31


  • 5


  • 1