The molecular identity of the mitochondrial Ca2+ sequestration system: Minireview Review uri icon

Overview

MeSH Major

  • Calcium
  • Mitochondria
  • Mitochondrial Proteins

abstract

  • There is ample evidence to suggest that a dramatic decrease in mitochondrial Ca(2+) retention may contribute to the cell death associated with stroke, excitotoxicity, ischemia and reperfusion, and neurodegenerative diseases. Mitochondria from all studied tissues can accumulate and store Ca(2+) , but the maximum Ca(2+) storage capacity varies widely and exhibits striking tissue specificity. There is currently no explanation for this fact. Precipitation of Ca(2+) and phosphate in the mitochondrial matrix has been suggested to be the major form of storage of accumulated Ca(2+) in mitochondria. How this precipitate is formed is not known. The molecular identity of almost all proteins involved in Ca(2+) transport, storage and formation of the permeability transition pore is also unknown. This review summarizes studies aimed at identifying these proteins, and describes the properties of a known mitochondrial protein that may be involved in Ca(2+) transport and the structure of the permeability transition pore.

publication date

  • September 2010

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3725145

Digital Object Identifier (DOI)

  • 10.1111/j.1742-4658.2010.07756.x

PubMed ID

  • 20659159

Additional Document Info

start page

  • 3652

end page

  • 63

volume

  • 277

number

  • 18