Clinical genetics of hereditary colorectal cancer. Review uri icon

Overview

MeSH

  • Clinical Medicine
  • Colorectal Neoplasms, Hereditary Nonpolyposis
  • Genetic Testing
  • Hamartoma Syndrome, Multiple
  • Humans
  • Peutz-Jeghers Syndrome

MeSH Major

  • Colorectal Neoplasms
  • Genetic Predisposition to Disease
  • Neoplastic Syndromes, Hereditary

abstract

  • Colorectal cancer (CRC) is a common disease, and approximately 25% of patients have a familial component. High-penetrance singlegene germline mutations conferring a true hereditary susceptibility account for around 5% to 6% of all cases. Lynch syndrome is the most common hereditary form of colorectal cancer. Much of the hereditary component in the remaining familial cases of CRC is likely polygenic, and many of the genetic changes involved are as yet unidentified. This article addresses the most clinically important CRC genetic syndromes. Copyright 2010 Elsevier Inc. All rights reserved.

publication date

  • October 2010

has subject area

  • Clinical Medicine
  • Colorectal Neoplasms
  • Colorectal Neoplasms, Hereditary Nonpolyposis
  • Genetic Predisposition to Disease
  • Genetic Testing
  • Hamartoma Syndrome, Multiple
  • Humans
  • Neoplastic Syndromes, Hereditary
  • Peutz-Jeghers Syndrome

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.hoc.2010.06.006

PubMed ID

  • 20816577

Additional Document Info

start page

  • 837

end page

  • 859

volume

  • 24

number

  • 5