Calcium and mitochondrial reactive oxygen species generation: how to read the facts. Review uri icon



  • Animals
  • Humans
  • Mitochondrial Diseases

MeSH Major

  • Calcium
  • Mitochondria
  • Reactive Oxygen Species


  • A number of recent discoveries indicate that abnormal Ca2+ signaling, oxidative stress, and mitochondrial dysfunction are involved in the neuronal damage in Alzheimer's disease. However, the literature on the interactions between these factors is controversial especially in the interpretation of the cause-effect relationship between mitochondrial damage induced by Ca2+ overload and the production of reactive oxygen species (ROS). In this review, we survey the experimental observations on the Ca2+-induced mitochondrial ROS production, explain the sources of controversy in interpreting these results, and discuss the different molecular mechanisms underlying the effect of Ca2+ on the ROS emission by brain mitochondria.

publication date

  • 2010

has subject area

  • Animals
  • Calcium
  • Humans
  • Mitochondria
  • Mitochondrial Diseases
  • Reactive Oxygen Species



  • Journal Article
  • Review



  • eng

PubMed Central ID

  • PMC3056350

Digital Object Identifier (DOI)

  • 10.3233/JAD-2010-100465

PubMed ID

  • 20421693

Additional Document Info

start page

  • S413

end page

  • S426


  • 20 Suppl 2