Tumor-initiating cells are rare in many human tumors Letter uri icon

Overview

MeSH Major

  • Neoplasms
  • Neoplasms, Experimental

abstract

  • Tumor-initiating cells (TICs) are defined by their ability to form tumors after xenotransplantation in immunodeficient mice and appear to be relatively rare in most human cancers. Recent data in melanoma indicate that the frequency of TICs increases dramatically via more permissive xenotransplantation conditions, raising the possibility that the true frequency of TICs has been greatly underestimated in most human tumors. We compared the growth of human pancreatic, non-small cell lung, and head and neck carcinomas in NOD/SCID and NSG mice. Although TIC frequency was detected up to 10-fold higher in NSG mice, it remained low (<1 in 2500 cells) in all cases. Moreover, aldehyde dehydrogenase-positive (ALDH(+)) and CD44(+)CD24(+) cells, phenotypically distinct cells enriched in TICs, were equally tumorigenic in NOD/SCID and NSG mice. Our findings demonstrate that TICs are rare in these cancers and that the identification of TICs and their frequency in other human malignancies should be validated via primary tumors and highly permissive xenotransplantation conditions.

publication date

  • September 3, 2010

Research

keywords

  • Letter

Identity

Language

  • eng

PubMed Central ID

  • PMC2945729

Digital Object Identifier (DOI)

  • 10.1016/j.stem.2010.08.009

PubMed ID

  • 20804964

Additional Document Info

start page

  • 279

end page

  • 82

volume

  • 7

number

  • 3