EZH2 mutations: Mutating the epigenetic machinery in myeloid malignancies Article uri icon

Overview

MeSH Major

  • Biopsy, Needle
  • Bone Marrow Cells
  • Femur
  • Tissue and Organ Harvesting

abstract

  • Two recent studies identified loss-of-function mutations in the histone H3 methyltransferase EZH2 in myelodysplastic syndromes and myeloproliferative neoplasms, provided further demonstration of mutations in epigenetic modifiers in myeloid malignancies, and suggest EZH2 functions as a tumor-suppressor gene in these malignancies rather than an oncogene as in some other malignancies. © 2010 Elsevier Inc.

publication date

  • August 2010

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.ccr.2010.07.006

Additional Document Info

start page

  • 105

end page

  • 107

volume

  • 18

number

  • 2