Zoledronic acid use in patients with bone metastases from renal cell carcinoma or bladder cancer Review uri icon


MeSH Major

  • Bone Neoplasms
  • Carcinoma, Renal Cell
  • Diphosphonates
  • Imidazoles
  • Kidney Neoplasms
  • Urinary Bladder Neoplasms


  • Approximately 30% of patients with renal cell carcinoma (RCC) and 40% of patients with bladder cancer develop bone metastases that can disrupt normal bone homeostasis and place patients at risk for potentially life-limiting skeletal-related events (SREs). In the absence of bone-directed therapies, patients with RCC may experience up to four SREs per year. In patients with bone metastases from RCC or bladder cancer, zoledronic acid (ZOL) significantly reduced the risk of SREs compared with placebo. In addition to its bone-protective effects, preclinical and early clinical evidence indicates that ZOL prevents tumor progression. For example, retrospective subset analysis in patients with RCC indicated that ZOL extended time to disease progression and demonstrated a trend toward improved overall survival compared with placebo. Additionally, a study in patients with bone metastases from bladder cancer demonstrated that ZOL improved 1-year overall survival compared with placebo. Bone metastases place a heavy burden on patients with RCC or bladder cancer, and early, continuous treatment with ZOL may provide anticancer benefits in addition to important patient quality of life.

publication date

  • June 2010



  • Review



  • eng

Digital Object Identifier (DOI)

  • 10.1053/j.seminoncol.2010.06.001

PubMed ID

  • 20682371

Additional Document Info

start page

  • S38

end page

  • 44


  • 37


  • SUPPL.