Visual P2-N2 complex and arousal at the time of encoding predict the time domain characteristics of amnesia for multiple intravenous anesthetic drugs in humans Academic Article uri icon

Overview

MeSH Major

  • Amnesia
  • Anesthetics, Intravenous
  • Arousal
  • Evoked Potentials, Visual
  • Parietal Lobe
  • Reaction Time

abstract

  • In humans, the amnesia caused by multiple intravenous anesthetic drugs is characterized by arousal-related effects on initial trace strength, and a subsequent decay predicted by attenuation of the P2-N2 complex at encoding. The authors propose that the failure of normal memory consolidation follows drug-induced disruption of interregional synchrony critical for neuronal plasticity and discuss their findings in the framework of memory systems theory.

publication date

  • August 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2910207

Digital Object Identifier (DOI)

  • 10.1097/ALN.0b013e3181dfd401

PubMed ID

  • 20613477

Additional Document Info

start page

  • 313

end page

  • 26

volume

  • 113

number

  • 2