MicroRNAs: Small RNAs with big effects Review uri icon

Overview

MeSH Major

  • MicroRNAs

abstract

  • MicroRNAs (miRNAs) are evolutionarily conserved, small ( approximately 20-25 nucleotides), single-stranded molecules that suppress the expression of protein-coding genes by translational repression, messenger RNA degradation, or both. More than 700 miRNAs have been identified in the human genome. Amazingly, a single miRNA can regulate the expression of hundreds of mRNAs or proteins within a cell. The small RNAs are fast emerging as master regulators of innate and adaptive immunity and likely to play a pivotal role in transplantation. The clinical application of RNA sequencing ("next-generation sequencing") should facilitate transcriptome profiling at an unprecedented resolution. We provide an overview of miRNA biology and their hypothesized roles in transplantation.

publication date

  • July 27, 2010

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3094098

Digital Object Identifier (DOI)

  • 10.1097/TP.0b013e3181e913c2

PubMed ID

  • 20574417

Additional Document Info

start page

  • 105

end page

  • 12

volume

  • 90

number

  • 2