Pulmonary alveolar proteinosis in a kidney transplant: A rare complication of sirolimus Review uri icon

Overview

MeSH Major

  • Immunosuppressive Agents
  • Kidney Failure, Chronic
  • Kidney Transplantation
  • Pulmonary Alveolar Proteinosis
  • Sirolimus

abstract

  • Pulmonary alveolar proteinosis (PAP) has been associated with the immunosuppressant sirolimus in transplant patients. PAP is a progressive lung disease characterized by the accumulation of surfactant-like material in the lungs leading to decreased pulmonary function with shortness of breath and cough as common symptoms. We report a rare case of sirolimus-associated PAP in a kidney transplant recipient with a history of end-stage renal disease secondary to haemolytic uraemic syndrome (HUS) and review of the literature. Discontinuation of sirolimus and initiation of tacrolimus led to resolution of PAP without recurrence of HUS.

publication date

  • August 2010

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1093/ndt/gfq265

PubMed ID

  • 20484303

Additional Document Info

start page

  • 2795

end page

  • 8

volume

  • 25

number

  • 8