A review of endothelial dysfunction in diabetes: A focus on the contribution of a dysfunctional eNOS Review uri icon

Overview

MeSH Major

  • Diabetes Mellitus
  • Endothelium, Vascular
  • Nitric Oxide Synthase Type III
  • Vasoconstriction

abstract

  • Although the etiology of vascular dysfunction in diabetes has been extensively investigated in both humans as well as animal models of human diabetes, the relative importance of the cellular pathways involved is still not fully understood. In this review, we focus on reviewing the literature that provides insights into how an acute exposure to hyperglycemia results in a dysregulation of endothelial nitric oxide synthase function, the subsequent downstream effects of endothelial nitric oxide synthase dysregulation, and the development of endothelial dysfunction.

publication date

  • May 2010

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.jash.2010.02.004

PubMed ID

  • 20470995

Additional Document Info

start page

  • 102

end page

  • 15

volume

  • 4

number

  • 3