Design of an injectable synthetic and biodegradable surgical biomaterial Academic Article uri icon

Overview

MeSH Major

  • Biocompatible Materials

abstract

  • We report the design of an injectable synthetic and biodegradable polymeric biomaterial comprised of polyethylene glycol and a polycarbonate of dihydroxyacetone (MPEG-pDHA). MPEG-pDHA is a thixotropic physically cross-linked hydrogel, displays rapid chain relaxation, is easily extruded through narrow-gauge needles, biodegrades into inert products, and is well tolerated by soft tissues. We demonstrate the clinical utility of MPEG-pDHA in the prevention of seroma, a common postoperative complication following ablative and reconstructive surgeries, in an animal model of radical breast mastectomy. This polymer holds significant promise for clinical applicability in a host of surgical procedures ranging from cosmetic surgery to cancer resection.

publication date

  • June 15, 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2890725

Digital Object Identifier (DOI)

  • 10.1073/pnas.0811529107

PubMed ID

  • 20534478

Additional Document Info

start page

  • 11014

end page

  • 9

volume

  • 107

number

  • 24