New dimensions in vascular engineering: opportunities for cancer biology. Academic Article uri icon

Overview

MeSH

  • Animals
  • Cell Culture Techniques
  • Cell Transformation, Neoplastic
  • Humans
  • Neovascularization, Physiologic
  • Regenerative Medicine
  • Tissue Scaffolds

MeSH Major

  • Neoplasms
  • Neovascularization, Pathologic
  • Tissue Engineering

abstract

  • Angiogenesis is a fundamental prerequisite for tissue growth and thus an attractive target for cancer therapeutics. However, current efforts to halt tumor growth using antiangiogenic agents have been met with limited success. A reason for this may be that studies aimed at understanding tissue and organ formation have to this point utilized two-dimensional cell culture techniques, which fail to faithfully mimic the pathological architecture of disease in an in vivo context. In this issue of Tissue Engineering, the work of Fischbach-Teschl's group manipulate such variables as oxygen concentration, culture three-dimensionality, and cell-extracellular matrix interactions to more closely approximate the biophysical and biochemical microenvironment of tumor angiogenesis. In this article, we discuss how novel tissue engineering platforms provide a framework for the study of tumorigenesis under pathophysiologically relevant in vitro culture conditions.

publication date

  • July 2010

has subject area

  • Animals
  • Cell Culture Techniques
  • Cell Transformation, Neoplastic
  • Humans
  • Neoplasms
  • Neovascularization, Pathologic
  • Neovascularization, Physiologic
  • Regenerative Medicine
  • Tissue Engineering
  • Tissue Scaffolds

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2947931

Digital Object Identifier (DOI)

  • 10.1089/ten.TEA.2010.0183

PubMed ID

  • 20367255

Additional Document Info

start page

  • 2157

end page

  • 2159

volume

  • 16

number

  • 7