Integrative Genomic Profiling of Human Prostate Cancer Academic Article uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Gene Expression Profiling
  • Genome, Human
  • Oncogene Proteins, Fusion
  • Prostatic Neoplasms

abstract

  • Annotation of prostate cancer genomes provides a foundation for discoveries that can impact disease understanding and treatment. Concordant assessment of DNA copy number, mRNA expression, and focused exon resequencing in 218 prostate cancer tumors identified the nuclear receptor coactivator NCOA2 as an oncogene in approximately 11% of tumors. Additionally, the androgen-driven TMPRSS2-ERG fusion was associated with a previously unrecognized, prostate-specific deletion at chromosome 3p14 that implicates FOXP1, RYBP, and SHQ1 as potential cooperative tumor suppressors. DNA copy-number data from primary tumors revealed that copy-number alterations robustly define clusters of low- and high-risk disease beyond that achieved by Gleason score. The genomic and clinical outcome data from these patients are now made available as a public resource.

publication date

  • July 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3198787

Digital Object Identifier (DOI)

  • 10.1016/j.ccr.2010.05.026

PubMed ID

  • 20579941

Additional Document Info

start page

  • 11

end page

  • 22

volume

  • 18

number

  • 1