Rapid chemical antagonism of neuromuscular blockade by l-cysteine adduction to and inactivation of the olefinic (double-bonded) isoquinolinium diester compounds gantacurium (AV430A), CW 002, and CW 011 Academic Article uri icon

Overview

MeSH Major

  • Cysteine
  • Isoquinolines
  • Maleates
  • Neuromuscular Blockade
  • Neuromuscular Blocking Agents

abstract

  • L-cysteine adduction occurs at different rates by design in olefinic isoquinolinium diester neuromuscular blockers, yielding corresponding durations of action. Antagonism by exogenous L-cysteine is superior to anticholinesterases, inducing inactivation of the active molecules to restore function rapidly at any time.

publication date

  • July 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1097/ALN.0b013e3181dc1b5b

PubMed ID

  • 20526187

Additional Document Info

start page

  • 58

end page

  • 73

volume

  • 113

number

  • 1