Acute myeloid leukemia stem cells: Seek and destroy Review uri icon

Overview

MeSH Major

  • Antigens, CD
  • Antineoplastic Agents
  • Biomarkers, Tumor
  • Leukemia, Myeloid, Acute
  • Neoplastic Stem Cells

abstract

  • Most adult patients with acute myeloid leukemia (AML) die from their disease. Relapses are frequent even after aggressive multiagent chemotherapy and allogeneic stem cell transplantation. AML is a biologically heterogeneous disease, characterized by frequent cytogenetic abnormalities and an increasing spectrum of genetic mutations and molecular aberrations. Laboratory data suggest that AML originates from a rare population of cells, termed leukemic stem cells (LSCs) or leukemia-initiating cells, which are capable of self-renewal, proliferation and differentiation. These cells may persist after treatment and are probably responsible for disease relapse. This review will describe bench and translational research in LSCs and discuss how the data should be used to change the direction of developmental therapeutics and clinical trials in AML.

publication date

  • December 2009

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1586/ehm.09.53

PubMed ID

  • 21082958

Additional Document Info

start page

  • 663

end page

  • 72

volume

  • 2

number

  • 6