A paucity of heterochromatin at functional human neocentromeres
Chromosomal Proteins, Non-Histone
Chromosomes, Human, Pair 8
Tandem Repeat Sequences
This high-resolution mapping suggests that H3K4me2 does not seem sufficiently abundant to play a structural role at neocentromeres, as proposed for endogenous centromeres. Large domains of heterochromatin also do not appear necessary for centromere function. Thus, this study provides important insight into the structural requirements of human centromere function.