A paucity of heterochromatin at functional human neocentromeres Academic Article uri icon

Overview

MeSH Major

  • Autoantigens
  • Centromere
  • Chromosomal Proteins, Non-Histone
  • Chromosome Breakpoints
  • Chromosomes, Human, Pair 8
  • Tandem Repeat Sequences

abstract

  • This high-resolution mapping suggests that H3K4me2 does not seem sufficiently abundant to play a structural role at neocentromeres, as proposed for endogenous centromeres. Large domains of heterochromatin also do not appear necessary for centromere function. Thus, this study provides important insight into the structural requirements of human centromere function.

publication date

  • April 2, 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2845132

Digital Object Identifier (DOI)

  • 10.1186/1756-8935-3-6

PubMed ID

  • 20210998

Additional Document Info

start page

  • 6

volume

  • 3

number

  • 1