Randomized, placebo-controlled, clinical trial of donepezil in vascular dementia: Differential effects by hippocampal size Academic Article uri icon

Overview

MeSH Major

  • Cognition
  • Dementia, Vascular
  • Hippocampus
  • Indans
  • Nootropic Agents
  • Piperidines

abstract

  • Patients treated with donepezil 5 mg/d demonstrated significant improvement in cognitive, but not global, function. Donepezil was relatively well tolerated; adverse events were consistent with current labeling. Mortality in the placebo group was unexpectedly low. The differential treatment response of VaD patients by hippocampal size suggests that hippocampal imaging warrants further investigation for understanding VaD.

publication date

  • June 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2954887

Digital Object Identifier (DOI)

  • 10.1161/STROKEAHA.109.570077

PubMed ID

  • 20395618

Additional Document Info

start page

  • 1213

end page

  • 21

volume

  • 41

number

  • 6