Evaluation of early osteochondral defect repair in a rabbit model utilizing fourier transform-infrared imaging spectroscopy, magnetic resonance imaging, and quantitative T2 mapping Academic Article uri icon


MeSH Major

  • Cartilage, Articular
  • Magnetic Resonance Imaging
  • Models, Animal
  • Spectroscopy, Fourier Transform Infrared


  • There was no significant difference in volume of repair tissue at either time point. At 6 weeks, placebo repair tissue demonstrated longer T2 values (p < 0.01) than TP-508 did. Although both placebo and TP-508 repair tissue demonstrated longer T2 values than adjacent normal cartilage did, the 6-week T2 values of the TP-508 specimens were closer to those of the adjacent normal cartilage than were the placebo values. FT-IRIS analysis demonstrated a significant increase in collagen content, integrity, and PG content of the TP-508 repair tissue from 3 to 6 weeks (p < or = 0.05). In addition, the collagen and PG content of the TP-508 samples were closer to normal cartilage at 3 weeks than were the placebo samples. Further, there was a significant inverse correlation between the T2 relaxation values and collagen orientation in the normal cartilage. However, there were no significant correlations between T2 relaxation values and any FT-IRIS parameter in the repair tissue. Together, the data demonstrate that MRI and FT-IRIS assessment of cartilage repair tissue provide molecular information that furthers understanding of the cartilage repair process.

publication date

  • June 2010



  • Academic Article



  • eng

PubMed Central ID

  • PMC2945312

Digital Object Identifier (DOI)

  • 10.1089/ten.tec.2009.0020

PubMed ID

  • 19586313

Additional Document Info

start page

  • 355

end page

  • 64


  • 16


  • 3