Echinacea purpurea aerial extract alters course of influenza infection in mice Academic Article uri icon

Overview

MeSH Major

  • Echinacea
  • Orthomyxoviridae Infections
  • Phytotherapy
  • Plant Extracts

abstract

  • Influenza infection is a major clinical problem and Echinacea purpurea, a widely consumed botanical product, is purported to alter the course of respiratory infections including influenza. Mice infected with WSN influenza A and treated with E. purpurea polysaccharide extract had less weight loss than untreated mice but similar pulmonary viral titers. Echinacea-treated mice had lower systemic and pulmonary KC and IL-10 levels and lower systemic IFN-gamma levels following influenza infection. These suggest that E. purpurea alters the clinical course of influenza infection in mice through modulation of cytokines and not direct antiviral activity.

publication date

  • May 21, 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3016056

Digital Object Identifier (DOI)

  • 10.1016/j.vaccine.2010.03.047

PubMed ID

  • 20382242

Additional Document Info

start page

  • 3956

end page

  • 62

volume

  • 28

number

  • 23