Susceptibility loci associated with prostate cancer progression and mortality Academic Article uri icon

Overview

MeSH Major

  • Genetic Predisposition to Disease
  • Neoplasm Recurrence, Local
  • Polymorphism, Single Nucleotide
  • Prostatic Neoplasms

abstract

  • We identified associations between prostate cancer susceptibility SNPs and clinical end points. The rs61752561 in KLK3 and rs2735839 in the KLK2-KLK3 intergenic region were strongly associated with prostate cancer-specific survival, and rs10486567 in the 7JAZF1 gene were associated with biochemical recurrence. A larger study will be required to independently validate these findings and determine the role of these SNPs in prognostic models.

publication date

  • May 15, 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3732009

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-10-0028

PubMed ID

  • 20460480

Additional Document Info

start page

  • 2819

end page

  • 32

volume

  • 16

number

  • 10