Ceramide-rich platforms in transmembrane signaling Review uri icon

Overview

MeSH Major

  • Ceramides
  • Membrane Microdomains
  • Signal Transduction

abstract

  • Recent evidence suggests that ceramide regulates stress signaling via reorganization of the plasma membrane. The focus of this review will be to discuss the mechanism by which acid sphingomyelinase (ASMase)-generated ceramide initiates transmembrane signaling in the plasma membrane exoplasmic leaflet. In particular, we review the unique biophysical properties of ceramide that render it proficient in formation of signaling domains termed ceramide-rich platforms (CRPs), and the role of CRPs in the pathophysiology of various diseases. The biomedical significance of CRPs makes these structures an attractive therapeutic target.

publication date

  • May 2010

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4440589

Digital Object Identifier (DOI)

  • 10.1016/j.febslet.2010.02.026

PubMed ID

  • 20178791

Additional Document Info

start page

  • 1728

end page

  • 40

volume

  • 584

number

  • 9