Gene expression profiling uncovers molecular classifiers for the recognition of anaplastic large-cell lymphoma within peripheral T-cell neoplasms Academic Article uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Gene Expression Profiling
  • Lymphoma, Large-Cell, Anaplastic
  • Lymphoma, T-Cell, Peripheral

abstract

  • We proved that experimentally controlled GEP in ALCL cell lines represents a powerful tool to identify meaningful signaling networks for the recognition of systemic primary T-NHL. The identification of a molecular signature specific for ALCL suggests that these T-NHLs may represent a unique entity discernible from other PTCLs, and that a restricted number of genes can be instrumental for clinical stratification and, possibly, therapy of T-NHL.

publication date

  • March 20, 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2008.20.9759

PubMed ID

  • 20159827

Additional Document Info

start page

  • 1583

end page

  • 90

volume

  • 28

number

  • 9