Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart Academic Article uri icon

Overview

MeSH Major

  • Apoptosis
  • Heart Failure
  • Heme Oxygenase-1

abstract

  • HO-1 induction in the failing heart is an important cardioprotective adaptation that opposes pathological LV remodeling, and this effect is mediated, at least in part, by CO-dependent inhibition of mitochondrial permeability transition and apoptosis. Augmentation of HO-1 or its product, CO, may represent a novel therapeutic strategy for ameliorating HF.

publication date

  • May 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2917269

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.109.905471

PubMed ID

  • 20404253

Additional Document Info

start page

  • 1912

end page

  • 25

volume

  • 121

number

  • 17