Severe asthma with fungal sensitization in a child: Response to itraconazole therapy Academic Article uri icon

Overview

MeSH Major

  • Antifungal Agents
  • Aspergillosis, Allergic Bronchopulmonary
  • Asthma
  • Fungi
  • Itraconazole
  • Rhinitis, Allergic, Perennial

abstract

  • People with severe asthma with fungal sensitization may represent an underdiagnosed subset of patients with refractory disease. It is important to know that such patients may benefit from adjunct treatment with antifungal agents. We describe here the case of a child with refractory asthma, persistent airway obstruction, a serum immunoglobulin E level of >20000 IU/mL, and severe eosinophilic airway infiltration. Although he did not meet diagnostic criteria for allergic bronchopulmonary aspergillosis, he demonstrated evidence of sensitization to several fungi and responded dramatically to the addition of itraconazole therapy. We also discuss emerging hypotheses regarding fungal-induced asthma.

publication date

  • May 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1542/peds.2009-2443

PubMed ID

  • 20385639

Additional Document Info

start page

  • e1255

end page

  • 8

volume

  • 125

number

  • 5