Key role of CD36 in toll-like receptor 2 signaling in cerebral ischemia Academic Article uri icon

Overview

MeSH Major

  • Antigens, CD36
  • Brain Ischemia
  • Inflammation Mediators
  • Signal Transduction
  • Toll-Like Receptor 2

abstract

  • In the brain, TLR2/1 signaling requires CD36. The cooperative signaling of TLR2/1 and CD36 is a critical factor in the inflammatory response and tissue damage evoked by cerebral ischemia. Thus, suppression of CD36-TLR2/1 signaling could be a valuable approach to minimize postischemic inflammation and the attendant brain injury.

publication date

  • May 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2950279

Digital Object Identifier (DOI)

  • 10.1161/STROKEAHA.109.572552

PubMed ID

  • 20360550

Additional Document Info

start page

  • 898

end page

  • 904

volume

  • 41

number

  • 5