The role of cytotoxic and regulatory T cells in relapsed/refractory hodgkin lymphoma Academic Article uri icon


MeSH Major

  • Forkhead Transcription Factors
  • Granzymes
  • Hodgkin Disease
  • Poly(A)-Binding Proteins
  • T-Lymphocytes, Cytotoxic
  • T-Lymphocytes, Regulatory


  • Recent data suggests the presence of cytotoxic (TIA-1 and granzyme B+) and regulatory T-cells (FOXP3+) in classical Hodgkin lymphoma (cHL) tissues has been shown to correlate with poor overall survival in mainly diagnostic biopsies. By tissue microarray analyses, we extend this observation to a cohort of relapsed/refractory cHL tissue biopsies and analyze immunohistochemical expression of FOXP3, TIA-1, and granzyme B in the inflammatory background and the tumor microenvironment. High expression of TIA-1 (>50%) correlated with poor overall survival (P<0.0001), low expression of FOXP3 (<25%) correlated with poor overall survival (P<0.01), and combined high TIA-1 (>50%) and low FOXP3 (<25%) correlated with poor overall survival (P<0.0001). Expression of cytotoxic and regulatory T-cells shows prognostic significance in the relapsed/refractory clinical setting of cHL.

publication date

  • May 2010



  • Academic Article



  • eng

PubMed Central ID

  • PMC3260943

Digital Object Identifier (DOI)

  • 10.1097/PAI.0b013e3181c7138b

PubMed ID

  • 20065852

Additional Document Info

start page

  • 206

end page

  • 11


  • 18


  • 3