Nanoinformatics and DNA-based computing: catalyzing nanomedicine. Review uri icon

Overview

MeSH

  • Child
  • Diagnosis, Computer-Assisted
  • Genetic Predisposition to Disease
  • Humans
  • Precision Medicine
  • Systems Biology
  • Systems Integration
  • Translational Medical Research

MeSH Major

  • Computational Biology
  • Databases, Genetic
  • Nanomedicine
  • Nanotechnology
  • Pediatrics

abstract

  • Five decades of research and practical application of computers in biomedicine has given rise to the discipline of medical informatics, which has made many advances in genomic and translational medicine possible. Developments in nanotechnology are opening up the prospects for nanomedicine and regenerative medicine where informatics and DNA computing can become the catalysts enabling health care applications at sub-molecular or atomic scales. Although nanomedicine promises a new exciting frontier for clinical practice and biomedical research, issues involving cost-effectiveness studies, clinical trials and toxicity assays, drug delivery methods, and the implementation of new personalized therapies still remain challenging. Nanoinformatics can accelerate the introduction of nano-related research and applications into clinical practice, leading to an area that could be called "translational nanoinformatics." At the same time, DNA and RNA computing presents an entirely novel paradigm for computation. Nanoinformatics and DNA-based computing are together likely to completely change the way we model and process information in biomedicine and impact the emerging field of nanomedicine most strongly. In this article, we review work in nanoinformatics and DNA (and RNA)-based computing, including applications in nanopediatrics. We analyze their scientific foundations, current research and projects, envisioned applications and potential problems that might arise from them.

publication date

  • May 2010

has subject area

  • Child
  • Computational Biology
  • Databases, Genetic
  • Diagnosis, Computer-Assisted
  • Genetic Predisposition to Disease
  • Humans
  • Nanomedicine
  • Nanotechnology
  • Pediatrics
  • Precision Medicine
  • Systems Biology
  • Systems Integration
  • Translational Medical Research

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1203/PDR.0b013e3181d6245e

PubMed ID

  • 20118825

Additional Document Info

start page

  • 481

end page

  • 489

volume

  • 67

number

  • 5