Metabolism and the leukemic stem cell Comment uri icon

Overview

MeSH Major

  • Hematopoiesis
  • Leukemia
  • Neoplastic Stem Cells
  • Reactive Oxygen Species

abstract

  • Acute leukemias are clonal disorders of hematopoiesis wherein a leukemic stem cell (LSC) acquires mutations that confer the capacity for unlimited self-renewal, impaired hematopoietic differentiation, and enhanced proliferation to the leukemic clone. Many recent advances in understanding the biology of leukemia have come from studies defining specific genetic and epigenetic abnormalities in leukemic cells. Three recent articles, however, further our understanding of leukemia biology by elucidating specific abnormalities in metabolic pathways in leukemic hematopoiesis. These studies potentially converge on the concept that modulation of reactive oxygen species (ROS) abundance may influence the pathogenesis and treatment of acute myeloid leukemia (AML).

publication date

  • April 12, 2010

Research

keywords

  • Comment

Identity

Digital Object Identifier (DOI)

  • 10.1084/jem.20100523

PubMed ID

  • 20368582

Additional Document Info

start page

  • 677

end page

  • 80

volume

  • 207

number

  • 4