18F-FDG PET of locally invasive breast cancer and association of estrogen receptor status with standardized uptake value: microarray and immunohistochemical analysis. Academic Article uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Fluorodeoxyglucose F18
  • Oligonucleotide Array Sequence Analysis
  • Receptors, Estrogen

abstract

  • In locally invasive primary breast cancer, ER-negative tumors display higher (18)F-FDG uptake than ER-positive tumors. Microarray analysis confirms these data and identifies genes associated with increased glucose use as measured by PET. These genes significantly overlap those of a previously validated ER-status molecular phenotype. These preliminary data support a growing body of evidence that ER-positive and ER-negative breast cancers have distinct disease-specific patterns. Further validation prospectively and with larger numbers will be required to establish a robust molecular signature for metabolic uptake and patterns of aggressive behavior in advanced breast cancer.

publication date

  • April 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4141648

PubMed ID

  • 20237034

Additional Document Info

start page

  • 543

end page

  • 50

volume

  • 51

number

  • 4