Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells but not in pericytes Academic Article uri icon

Overview

MeSH Major

  • ADAM Proteins
  • Endothelial Cells
  • Melanoma, Experimental
  • Neovascularization, Pathologic
  • Pericytes
  • Retinal Neovascularization

abstract

  • These results provide the first evidence for a role for ADAM17 in pathological neovascularization in vivo. Because ADAM17 does not appear to be required for normal developmental angiogenesis or vascular homeostasis, it could emerge as a good target for treatment of pathological neovascularization.

publication date

  • March 19, 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2842448

Digital Object Identifier (DOI)

  • 10.1161/CIRCRESAHA.109.207415

PubMed ID

  • 20110534

Additional Document Info

start page

  • 932

end page

  • 40

volume

  • 106

number

  • 5