Germline BRCA mutations denote a clinicopathologic subset of prostate cancer Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • Genes, BRCA1
  • Genes, BRCA2
  • Germ-Line Mutation
  • Prostatic Neoplasms

abstract

  • BRCA2 mutation carriers had an increased risk of prostate cancer and a higher histologic grade, and BRCA1 or BRCA2 mutations were associated with a more aggressive clinical course. These results may have implications for tailoring clinical management of this subset of hereditary prostate cancer.

publication date

  • April 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3713614

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-09-2871

PubMed ID

  • 20215531

Additional Document Info

start page

  • 2115

end page

  • 21

volume

  • 16

number

  • 7