Common Functional Genetic Variants in Catecholamine Storage Vesicle Protein Promoter Motifs Interact to Trigger Systemic Hypertension Academic Article uri icon

Overview

MeSH Major

  • Chromogranin B
  • Hypertension
  • Promoter Regions, Genetic

abstract

  • The common CHGB promoter variants A-296C and A-261T, and their consequent haplotypes, alter binding of specific transcription factors to influence gene expression in cella as well as BP in vivo. Such variation contributes substantially to risk for human hypertension. Involvement of the sex-specific factor SRY suggests a novel mechanism for development of sexual dimorphism in BP.

publication date

  • April 6, 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2889490

Digital Object Identifier (DOI)

  • 10.1016/j.jacc.2009.11.064

PubMed ID

  • 20359597

Additional Document Info

start page

  • 1463

end page

  • 75

volume

  • 55

number

  • 14