Hydrazone ligation strategy to assemble multifunctional viral nanoparticles for cell imaging and tumor targeting. Academic Article uri icon

Overview

MeSH

  • Animals
  • HT29 Cells
  • Humans
  • Mice

MeSH Major

  • Drug Delivery Systems
  • Hydrazones
  • Image Enhancement
  • Nanostructures
  • Virion

abstract

  • Multivalent nanoparticle platforms are attractive for biomedical applications because of their improved target specificity, sensitivity, and solubility. However, their controlled assembly remains a considerable challenge. An efficient hydrazone ligation chemistry was applied to the assembly of Cowpea mosaic virus (CPMV) nanoparticles with individually tunable levels of a VEGFR-1 ligand and a fluorescent PEGylated peptide. The nanoparticles recognized VEGFR-1 on endothelial cell lines and VEGFR1-expressing tumor xenografts in mice, validating targeted CPMV as a nanoparticle platform in vivo.

publication date

  • March 10, 2010

has subject area

  • Animals
  • Drug Delivery Systems
  • HT29 Cells
  • Humans
  • Hydrazones
  • Image Enhancement
  • Mice
  • Nanostructures
  • Virion

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3988696

Digital Object Identifier (DOI)

  • 10.1021/nl1002526

PubMed ID

  • 20163184

Additional Document Info

start page

  • 1093

end page

  • 1097

volume

  • 10

number

  • 3