Dynamics of liquid plugs of buffer and surfactant solutions in a micro-engineered pulmonary airway model. Academic Article uri icon

Overview

MeSH

  • Air
  • Buffers
  • Phosphates
  • Pressure
  • Solutions
  • Surface Properties
  • Wettability

MeSH Major

  • Biomimetics
  • Respiratory System
  • Surface-Active Agents

abstract

  • We describe a bioinspired microfluidic system that resembles pulmonary airways and enables on-chip generation of airway occluding liquid plugs from a stratified air-liquid two-phase flow. User-defined changes in the air stream pressure facilitated by mechanical components and tuning the wettability of the microchannels enable generation of well-defined liquid plugs. Significant differences are observed in liquid plug generation and propagation when surfactant is added to the buffer. The plug flow patterns suggest a protective role of surfactant for airway epithelial cells against pathological flow-induced mechanical stresses. We discuss the implications of the findings for clinical settings. This approach and the described platform will enable systematic investigation of the effect of different degrees of fluid mechanical stresses on lung injury at the cellular level and administration of exogenous therapeutic surfactants.

publication date

  • March 2, 2010

has subject area

  • Air
  • Biomimetics
  • Buffers
  • Phosphates
  • Pressure
  • Respiratory System
  • Solutions
  • Surface Properties
  • Surface-Active Agents
  • Wettability

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2827626

Digital Object Identifier (DOI)

  • 10.1021/la903038a

PubMed ID

  • 20017471

Additional Document Info

start page

  • 3744

end page

  • 3752

volume

  • 26

number

  • 5