Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • Aldehyde Dehydrogenase
  • Mesoderm
  • Neoplastic Stem Cells
  • Pancreatic Neoplasms

abstract

  • ALDH expression marks pancreatic cancer cells that have stem cell and mesenchymal features. The enhanced clonogenic growth and migratory properties of ALDH-positive pancreatic cancer cells suggest that they play a key role in the development of metastatic disease that negatively affects the overall survival of patients with pancreatic adenocarcinoma.

publication date

  • March 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2831049

Digital Object Identifier (DOI)

  • 10.1093/jnci/djp535

PubMed ID

  • 20164446

Additional Document Info

start page

  • 340

end page

  • 51

volume

  • 102

number

  • 5